| Primary Identifier | IPR000879 | Type | Family |
| Short Name | Guanylin |
| description | This entry represents the guanylin family. Its members include guanylate cyclase activator 2A and 2B. They are endogenous activators of intestinal guanylate cyclases. Guanylin, a 15-amino-acid peptide, is an endogenous ligand of the intestinal receptor guanylate cyclase-C, known as STaR [, ]. Upon receptor binding, guanylin increases the intracellular concentration of cGMP, it induces chloride secretion and decreases intestinal fluid absorption, ultimately causing diarrhoea []. The peptide stimulates the enzyme through the same receptor binding region as the heat-stable enterotoxins []. |
