| Primary Identifier | IPR034245 | Type | Domain |
| Short Name | EphB3_rcpt_lig-bd |
| description | This entry represents the ligand-binding domain found in ephrin type-B receptor 3 (EphB3). EphB3 plays a role in cell positioning in the gastrointestinal tract by being preferentially expressed in Paneth cells []. It also has been implicated in early colorectal cancer and early stage squamous cell lung cancer []. Class EphB receptors bind to transmembrane ephrin-B ligands. There are six vertebrate EhpB receptors (EphB1-6), which display promiscuous interactions with three ephrin-B ligands [].Ephrin receptors (EphRs) comprise the largest subfamily of receptor tyrosine kinases (RTKs). EphRs contain a ligand binding domain and two fibronectin repeats extracellularly, a transmembrane segment, and a cytoplasmic tyrosine kinase domain. Binding of the ephrin ligand to EphR requires cell-cell contact since both are anchored to the plasma membrane. The resulting downstream signals occur bidirectionally in both EphR-expressing cells (forward signaling) and ephrin-expressing cells (reverse signaling) []. |
