| Primary Identifier | IPR034231 | Type | Domain |
| Short Name | EphB1_rcpt_lig-bd |
| description | This entry represents the ligand-binding domain found in ephrin type-B receptor 1 (EphB1). Using EphB1 knockout-mice, EphB1 has been shown to be essential to the development of long-term potentiation (LTP) [], a cellular model of synaptic plasticity, learning and memory formation [, , ].Class EphB receptors bind to transmembrane ephrin-B ligands. There are six vertebrate EhpB receptors (EphB1-6), which display promiscuous interactions with three ephrin-B ligands [].Ephrin receptors (EphRs) comprise thelargest subfamily of receptor tyrosine kinases (RTKs). EphRs contain a ligand binding domain and two fibronectin repeats extracellularly, a transmembrane segment, and a cytoplasmic tyrosine kinase domain. Binding of the ephrin ligand to EphR requires cell-cell contact since both are anchored to the plasma membrane. The resulting downstream signals occur bidirectionally in both EphR-expressing cells (forward signaling) and ephrin-expressing cells (reverse signaling) []. |
