| Primary Identifier | IPR000928 | Type | Domain |
| Short Name | SNAP-25_dom |
| description | This entry represents a domain found in the SNAP-25 family members. SNAP-25 (synaptosome-associated protein 25kDa) proteins are components of SNARE complexes, which are proposed to account for the specificity of membrane fusion and todirectly execute fusion by forming a tight complex (the SNARE or corecomplex) that brings the synaptic vesicle and plasma membranestogether. The SNAREs constitute a large family of proteins thatare characterised by 60-residue sequences known as SNARE motifs (),which have a high propensity to form coiled coils and often precedecarboxy-terminal transmembrane regions. The synaptic core complex is formed by four SNARE motifs (two fromSNAP25 and one each from synaptobrevin and syntaxin 1) that areunstructured in isolation but form a parallel four-helix bundle onassembly. The crystal structure of the core complex revealedthat the helix bundle is highly twisted and contains several salt bridges onthe surface, as well as layers of interior hydrophobic residues.However, a polar layer in the centre of the complex is formed by threeglutamines (two from SNAP25 and one from syntaxin 1) and one arginine(from synaptobrevin) [].Members of the SNAP-25 family contain a cluster of cysteine residues that can be palmitoylated for membrane attachment []. |
