| Primary Identifier | IPR034597 | Type | Family |
| Short Name | PRC |
| description | PGC-1-related coactivator (PRC or PPRC1) was first identified as a transcriptional coactivator that shares structural and functional features with PGC-1alpha. It belongs to the PGC-1 family []. Similar to other PGC-1 members, PRC has a function in growth-regulated mitochondrial biogenesis. Different from other PGC-1 family members, PRC mRNA is induced by serum growth factors in the absence of de novoprotein synthesis, which place the PRC gene in a class of immediate early or primary response genes []. In mice germ line, knock-out of PRC causes early embryonic lethality []. PRC is also required for the induction of an inflammatory/stress response to multiple metabolic insults [].The PGC-1 family members, including PGC-1alpha, PGC-1beta and PRC, are transcriptional coactivators that regulate cell metabolic processes ranging from mitochondrial biogenesis to oxidative respiration []. They target NRF-1, a transcription factor that binds to a palindromic sequence in the cytochrome c promoter and associate with the expression of many genes required for expression and function of the respiratory chain. They also bind to CREB (cAMP response element-binding protein) and ERRalpha (estrogen-related receptor alpha). However, knockout of individual components in the PGC-1 family can result in diverse phenotypes ranging from early embryonic lethality to complete viability with very mild effects on global mitochondrial content and function. They contain an N-terminal region with a nuclear receptor coactivator signature-LXXLL and a C-terminal region with a RS domain and a RNA recognition motif []. |
