| Primary Identifier | IPR010418 | Type | Family |
| Short Name | ECSIT |
| description | Activation of NF-kappaB as a consequence of signalling throughthe Toll and IL-1 receptors is a major element of innate immune responses. ECSIT (Evolutionarily conserved signaling intermediate in Toll pathway) plays an important role in signalling to NF-kappaB, functioning as an adapter protein of the Toll-like and IL-1 receptor signalling pathway and an intermediary in the signalling pathways between TRAF-6 and MEKK-1 []. It is part of the MCIA (mitochondrial complex I intermediate assembly) complex, involved in the assembly of mitochondrial complex I []. |
