| Primary Identifier | IPR063621 | Type | Domain |
| Short Name | Cacna2d1-4/CACHD1_middle |
| description | This entry represents a Cache domain found centrally in proteins of the calcium channel subunit alpha-2/delta family mainly in vertebrates. This includes CACHD1 (VWFA and cache domain-containing protein 1) and CACNA2D (voltage-dependent calcium channel subunit alpha-2/delta) proteins. These are single-pass type I membrane proteins that regulate voltage-dependent calcium channels. CACHD1 contains a VWFA domain () and two Cache domains, while CACNA2D proteins contain a VWFA domain and one Cache domain []. Cache domains are extracellular sensory domains that typically bind small ligands. CACHD1 interacts with Wnt receptors and regulates neuronal asymmetry in zebrafish brain development []. The specific ligand-binding properties of this domain remain to be determined. |
