| Primary Identifier | IPR046409 | Type | Homologous_superfamily |
| Short Name | PDC10_dimerisation_sf |
| description | Programmed cell death 10 protein (PDCD10/CCM3) is part of the CCM complex and is required for neuronal migration []. Outside of this complex, it is crucial in vascularization and in angiogenesis as it functions in vessel permeability and stability []. This protein plays an essential role in early embryonic angiogenesis and cardiovascular development. PDCD10/CCM3 interacts with a variety of proteins, including paxillin, membrane receptor vascular epidermal growth factor receptor 2, CCM complex component CCM2 and germinal centre kinase III proteins (GCKIII). PDCD10/CCM3 contains an N-terminal dimerisation domain and a C-terminal focal adhesion targeting-homology (FAT-H) domain [, , ].This entry represents the N-terminal dimerisation domain of PDC10/CCM3, consisting of four α-helices. This domain is also found at the C-terminal of GCKIIIs (STK24/MST3, STK25, STK26/MST4), which adopts a closely related fold. GCKIIIs are involved in the regulation of apoptosis, cell proliferation, polarity, migration, and cytoskeleton remodelling. This domain mediates homo and heterodimerization. PDCD10/CCM3 forms a heterodimer with GCKIIIs analogous to CCM3 homodimer [, ]. |
