| Primary Identifier | IPR022449 | Type | Family |
| Short Name | Kae1_arc |
| description | This family represents Kae1 and its homologues from Archaea. They belong to the Kae1/TsaD family. Its partner kinase Bud32 is fused with it in about half of the known archaeal genomes []. The pair, which appears universal in the archaea, corresponds to EKC/KEOPS complex in eukaryotes []. The first characterised member of the Kae1/TsaD family was annotated as Gcp for O-sialoglycoprotein endopeptidase [], but this activity could not be confirmed []. Later, its homologue, Kae1 from Pyrococcus abyssi, has been shown to have DNA-binding properties and apurinic-endonuclease activity []. Members of this family have since been studied in yeast, archaea and bacteria resulting in sometimes conflicting data, several proposed functions and annotations but no definitive characterisation. For instance, some members have been linked to DNA maintenance in bacteria and mitochondria []and transcription regulation and telomere homeostasis in eukaryotes [, ], but their function remained unclear. Recent research indicates that this family is involved in the biosynthesis of N6-threonylcarbamoyl adenosine, a universal modification found at position 37 of tRNAs that read codons beginning with adenine []. |
