Primary Identifier | IPR029917 | Type | Family |
Short Name | CapG |
description | Macrophage-capping protein (CapG) belongs to the Villin/Gelsolin family, whose members are Ca(2+)-dependent, multidomain regulators of the actin cytoskeleton []. CapG was first isolated from alveolar macrophages as an actin-modulating protein that reversibly cap the barbed ends of actin filaments []. Unlike most of the Villin/Gelsolin family members, it does not sever actin filaments []. It is involved in cell invasion and metastasis in several cancers [, ]. |