| Primary Identifier | IPR030195 | Type | Family |
| Short Name | ENT1 |
| description | Human Equilibrative, Nitrobenzylthioinosine (NBMPR)-sensitive Nucleoside Transporter ENT1 was the first identified member of the ENT family. ENT1 (also known as solute carrier family 29 member 1, SLC29A1) mediates both influx and efflux of nucleosides across the membrane, including adenosine and many anti-cancer nucleoside drugs [, ]. ENT1 has a topology of 11 transmembrane domains (TMDs) with a 6+5 topology in which the first 6 TM forms one bundle, termed the N-domain, and the final 5 TMs forms another bundle, the C-domain, with a hydrophilic loop between TMD6 and TMD7 [, ]. ENT1 -as ENT2- is localised in plasma membranes and is broadly expressed in tissues [, ]. |
