| Primary Identifier | IPR034743 | Type | Domain |
| Short Name | RH1 |
| description | The RH1 (RILP homology 1) protein-protein interaction domain is found in thefollowing animal Rab36-binding proteins:Rab interacting lysosomal proteins (RILP),RILP-like 1 (RILP-L1),RILP-like 2 (RILP-L2),JNK-interacting protein 3 (JIP3),JNK-interacting protein 4 (JIP4).It binds to the myosin Va globular tail domain (MyoVa-GTD) in mainlyhydrophobic interactions.The RH1 domain adopts an all-helical structure and forms ahomodimer with a four-helix bundle conformation to interact with MyoVa-GTD.The RH1 homodimer is structurally separated into two parts, the N-terminalfour-helix bundle formed by alpha2 and alpha3N and the C-terminal coiled-coilformed by alpha3C. The four-helix bundle in the RH1 dimer is mainly stabilizedby forming a hydrophobic core. The N-terminal small helix (alpha1) and itsfollowing loop pack on alpha2 from the same molecule and alpha3 from theneighbouring molecule and thus contribute to the bundle stability. The RH1homodimer is further strengthened by a coiled coil formed by the C-terminalhalf of the alpha3-helix [].This entry represents the entire RH1 domain. |
