| Primary Identifier | IPR019153 | Type | Family |
| Short Name | DDRGK_dom-contain |
| description | This is a family of proteins that contain a highly conserved DDRGK motif. In humans, DDRGK domain-containing protein 1 is a substrate adapter for ufmylation, the covalent attachment of the ubiquitin-like modifier UFM1 to substrate proteins, which plays a key role in reticulophagy (also called ER-phagy) []. It is also involved in cartilage development through SOX9, inhibiting the ubiquitin-mediated proteasomal degradation of this transcriptional regulator []. |
