| Primary Identifier | IPR032136 | Type | Domain |
| Short Name | NCF1_PBR/AIR |
| description | This entry represents the polybasic or autoinhibitory region (PBR/AIR, an arginine/lysine rich region) found after the second SH3 domain in neutrophil cytosol factor 1 (NCF1/p47phox) []. NCF1 is one of the cytosolic regulatory components of NADPH oxidase and consists of a PX domain at the N-terminal, two tandem SH3 domains, a PBR/AIR and a proline-rich region at the C-terminal. In the resting state, the SH3 domains of NCF1 are masked by an intramolecular interaction with the PBR/AIR, which maintains the enzyme in an inactive form []. |
