| Primary Identifier | IPR034781 | Type | Family |
| Short Name | SAFB1 |
| description | SAFB1 belongs to the scaffold attachment factor B (SAFB) family. It has many functions such as transcriptional repression and RNA splicing. It may also have a role in chromatin organization. It is involved in in numerous cellular processes including cell growth, stress response, and apoptosis []. It plays an important role in cancer, particularly in breast tumorigenesis []. Scaffold attachment factor B (SAFB) family members include SAFB1, SAFB2 and SAFB-like transcriptional modulator, SLTM. They contain an N-terminal DNA-binding (SAF-A/B, Acinus and PIAS, SAP) domain, an RNA-binding domain (RBD) and an C-terminal arginine/glycine motif RGG/RG domain. Their RGG/RG domain, which partially overlaps with a putative coiled-coil domain, is most conserved and is likely to be involved in protein-protein interactions []. |
