| Primary Identifier | IPR010655 | Type | Domain |
| Short Name | Clp1_C |
| description | The yeast Clp1 is a subunit of cleavage factor IA (CF IA) and is involved in mRNA cleavage and polyadenylation []. Clp1 also mediates interactions between CF IA and another complex of the yeast mRNA cleavage and polyadenylation machinery, the Cleavage-Polyadenylation Factor (CPF) []. It seems that human Clp1 and yeast Clp1 are not functional orthologues []. Human Clp1, and its archeal homologue [], but not yeast Clp1, are 5'-OH polynucleotide kinases. In humans Clp1 functions as a RNA kinase important in tRNA splicing [, ], and is also implicated in mRNA and siRNA maturation [, , ].This entry represents the C-terminal domain of Clp1. |
