| Primary Identifier | IPR015639 | Type | Family |
| Short Name | Ninjurin1 |
| description | Ninjurins are novel homophilic cell adhesion proteins involved in different processes such as inflammation, cell death, axonal growth, cell chemotaxis and angiogenesis [, ]. Ninjurin1 was named for its up regulation in Schwann cells following nerve injury [, ]. Ninjurin1 promotes cell adhesion by mediating homophilic interactions via its its extracellular N-terminal adhesion motif (N-NAM) and is involved in the progression of the inflammatory stress by promoting cell-to-cell interactions between immune cells and endothelial cells, being also involved in cell migration [, ]. Ninjurin1 mediates programmed and necrotic cell death [, ], playing a key role in the induction of plasma membrane rupture during programmed and necrotic cell death. It is also involved in striated muscle growth and differentiation []. |
