| Primary Identifier | IPR007019 | Type | Family |
| Short Name | SURF6 |
| description | This entry represents the surfeit locus protein SURF6 from mammals and its homologues from plants and fungi. In mammals, SURF6 is a component of the nucleolar matrix and has a strong binding capacity for nucleic acids []. SURF6 is always found in the nucleolus regardless of the phase of the cell cycle suggesting that it is a structural protein constitutively present in nucleolar substructures. A role in rRNA processing has been proposed for this protein. Saccharomyces cerevisiae member of the SURF-6 family, named Rrp14 (ribosomal RNA-processing protein 14), interacts with proteins involved in ribosomal biogenesis and cell polarity []. It is required for the synthesis of both 40S and 60S ribosomal subunits and may also play some direct role in correct positioning of the mitotic spindle during mitosis [, ]. |
