| Primary Identifier | IPR037908 | Type | Domain |
| Short Name | p23_NCB5OR |
| description | NAD(P)H cytochrome b5 oxidoreductase (NCB5OR) is widely expressed in human organs and tissues and is localized in the ER (endoplasmic reticulum) [, ]. It appears to play a critical role in maintaining viable pancreatic beta cells []. Mice homozygous for a targeted knockout (KO) of the gene encoding NCB5OR develop an early-onset nonautoimmune diabetes phenotype with a non-inflammatory beta-cell deficiency. The role of NCB5OR in beta cells may be in maintaining or regulating their redox status []. The gene encoding NCB5OR has been considered as a positional candidate for type II diabetes and other diabetes subtypes related to B-cell dysfunction; however, variation in its coding region does not appear not to be a major contributor to the pathogenesis of these diseases [].This entry represents the CS p23-like domain found in NCB5OR. In addition to a p23-like domain NCB5OR contains an N-terminal cytochrome b5 domain and a C-terminal cytochrome b5 oxidoreductase domain []. |
