| Primary Identifier | IPR034663 | Type | Domain |
| Short Name | cPKC_alpha |
| description | Protein kinases C (PKCs) constitute a family ofSer/Thr kinases. PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain [, ]. Conventional PKCs (cPKCs) have functional C1A and C1B domains, and a C2 domain. PKCs undergo three phosphorylations in order to take mature forms [, ]. In addition, cPKCs depend on calcium, DAG (1,2-diacylglycerol), and in most cases, phosphatidylserine for activation. There are three conventional PKC isoenzymes (alpha, beta, and gamma).PKC-alpha is expressed in many tissues and is associated with cell proliferation, apoptosis, and cell motility [, ]. It plays a role in the signalling of the growth factors PDGF, VEGF, EGF, and FGF. Abnormal levels of PKC-alpha have been detected in many transformed cell lines and several human tumours [, , , ]. In addition, PKC-alpha is required for HER2 dependent breast cancer invasion []. |
