| Primary Identifier | IPR007340 | Type | Domain |
| Short Name | Opacity-associatedA |
| description | The OapA domain gets its name from the Haemophilus influenzae protein OapA, which is required for the expression of colony opacity, thus opacity- associated protein A []. The OapA protein is required for efficient nasopharyngeal mucosal colonization, and its expression is associated with a distinctive transparent colony phenotype. OapA is thought to be a secreted protein, and its expression exhibits high-frequency phase variation []. The OapA protein contains a C-terminal OapA domain, which in the E. coli protein YtfB has been shown to bind to peptidoglycan []. A screen to identify factors that affect cell division in E. coli discovered that overproducing a fragment of YtfB, including its OapA domain, caused cells to grow as long filaments []. OapA domains are commonly associated with other domains that are involved in breaking peptidoglycan cross-links such as []. The OapA domain is distantly related to another peptidoglycan binding domain. |
