| Primary Identifier | IPR020373 | Type | Family |
| Short Name | Kgd4/YMR-31 |
| description | This entry represents the alpha-ketoglutarate dehydrogenase component 4 (Kgd4, also referred to as Ymr31/MRPS36) which was originally identified as a subunit of the mitochondrial ribosome. Through biochemical studies, it was shown that this protein co purifies with the oxoglutarate dehydrogenase complex (OGDC), also called alpha-ketoglutarate dehydrogenase complex (KGDH). Both mitochondrial ribosome 28S subunit and OGDC have a similar size and OGDC is highly abundant, being found to contaminate ribosomal preparations performed by sequential centrifugation steps []. Kgd4 plays an evolutionarily conserved role in the organization of mitochondrial α-KGDH complexes of fungi and animals which constitutes a molecular adaptor that is necessary to form a stable α-KGDH enzyme complex [, ]. |
