| Primary Identifier | IPR019361 | Type | Family |
| Short Name | HPF1 |
| description | Histone PARylation factor 1 (HPF1, previously known as C4orf27) is a key regulator of ADP-ribosylation signaling in response to DNA damage. It has been demonstrated that HPF1 forms a complex with PARP-1 (poly(ADP-ribose) polymerase 1) and is recruited to DNA lesions in a PARP-1-dependent manner, but independently of PARP-1 catalytic ADP-ribosylation activity. HPF1 has also been shown limit DNA damage-induced hyper-automodification of PARP-1 by promoting PARP-1-dependent in trans ADP-ribosylation of histones []. |
