| Primary Identifier | IPR032380 | Type | Domain |
| Short Name | PNKP_ligase_dom |
| description | This entry represents the ligase domain found in the PNKP (polynucleotide kinase-phosphatase) protein, which is a classical ligase nucleotidyltransferase module of bacteria. PNKP is the end-healing and end-sealing component of an RNA-repair system present in diverse bacteria from ten different phyla. RNA breakage by site-specific 'ribotoxins' is an ancient mechanism by which microbes respond to cellular stress and distinguish self from non-self. Ribotoxins are trans-esterifying endonucleases that generate 5'-OH and 2',3' cyclic phosphate termini. Repair of this type of RNA damage is feasible via sequential enzymatic end-healing and end-sealing steps []. |
