| Primary Identifier | IPR044342 | Type | Family |
| Short Name | Orf10_SARS-CoV-2 |
| description | This entry represents the Orf10 protein of Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), also known as 2019 novel coronavirus (2019-nCoV). SARS-CoV-2 causes the disease called "coronavirus disease 2019"(COVID-19). Orf10 appears to have no homologous proteins in SARS-CoV and other coronaviruses and is uniquely expressed in SARS-CoV-2 [, , ]. Recently, it was reported that Orf10 suppresses the IFN-I signalling pathway through the interaction with mitochondrial antiviral signalling protein (MAVS), which is degraded via Orf10-induced autophagy pathway. Orf10 interacts with NIX and LC3B and induces mitophagy []. |
