| Primary Identifier | IPR044395 | Type | Domain |
| Short Name | SF1_Hel-like_ZBD_rv |
| description | This entry represents the Cys/His rich zinc-binding domain (ZBD) of the helicase encoded on ORF1a and belongs to helicase superfamily 1 (SF1) from ronidovirus family including Gill-associated virus (GAV) []. The ZBD has 3 zinc-finger (ZnF1-3) motifs. Proteins containing this domain belong to a family of nindoviral replication helicases similar to SARS-NSP13 helicase, not included in this entry. The SARS-NSP13 ZBD is indispensable for helicase activity and interacts with SARS-Nsp12. SARS-Nsp12 can enhance the helicase activity of SARS-Nsp13 and can interact with SARS-Nsp13 on the third zinc finger motif of the ZBD []. |
