| Primary Identifier | IPR021532 | Type | Family |
| Short Name | NS7B_bCoV |
| description | This entry corresponds to ORF7b (also known as accessory protein 7b, NS7B, and 7b) from human SARS coronavirus (SARS-CoV) and SARS-CoV-2, which belong to the betacoronavirus B lineage (Sarbecovirus) [].ORF7b/NS7b from betacoronavirus in the B lineage are not related to NS7b proteins from other betacoronavirus lineages. The SARS-CoV ORF7b protein is a highly hydrophobic 43 amino acid protein which is homologous to an accessory but structural component of SARS-CoV virion. While ORF7b is packaged into virions, it is not required for the virus budding process, as gene 7 deletion viruses replicate efficiently in vitro and in vivo. Moreover, ORF7b possesses a transmembrane helical domain (TMD), between 9-29 amino acid residues, is necessary for its Golgi complex localization, as replacing it with the TMD from the human endoprotease furin results in aberrant localization [, ]. |
