| Primary Identifier | IPR010881 | Type | Family |
| Short Name | Herpes_LMP2 |
| description | This family consists of several Gammaherpesvirus latent membrane protein (LMP2) proteins. Epstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4) is a human gammaherpesvirus that infects and establishes latency in B lymphocytes in vivo. The latent membrane protein 2 (LMP2) gene is expressed in latently infected B cells and encodes two protein isoforms, LMP2A and LMP2B, that are identical except for an additional N-terminal 119 aa cytoplasmic domain which is present in the LMP2A isoform. LMP2A is thought to play a key role in either the establishment or the maintenance of latency and/or the reactivation of productive infection from the latent state. It modulates B-cell receptor signal transduction through its association with the cellular tyrosine kinases Lyn and Syk via specific motifs at the N-terminal tail domain. LMP2A also modulates the immune system reducing infected B cells recognition by EBV-specific CD8+ T cells []. The significance of LMP2B and its role in pathogenesis remain unclear. It is suggested that it may be a negative regulator of LMP2A [, ]. |
