| Primary Identifier | IPR034827 | Type | Domain |
| Short Name | TIA-1_RRM1 |
| description | This entry represents the RNA recognition motif 1 (RRM1) of TIA-1.TIA-1 is the 40kDa isoform of T-cell-restricted intracellular antigen-1 (TIA-1, also known as Cytotoxic granule associated RNA binding protein TIA1), a cytotoxic granule-associated RNA-binding protein mainly found in the granules of cytotoxic lymphocytes [, ]. TIA-1 regulate alternative pre-mRNA splicing by promoting the use of suboptimal 5' splice sites followed by uridine-rich intronic enhancer sequences. It can be phosphorylated by a serine/threonine kinase that is activated during Fas-mediated apoptosis, and functions as the granule component responsible for inducing apoptosis in cytolytic lymphocyte (CTL) targets []. Under conditions of rapid oxygen decline and extreme hypoxia, TIA-1 can aggregate with TIAR and suppress the HIF-1alpha pathway []. TIA-1 binds Zn, which is involved in formation and recruitment to stress granules [].TIA-1 is composed of three N-terminal highly homologous RNA recognition motifs (RRMs) and a glutamine-rich C-terminal auxiliary domain containing a lysosome-targeting motif. It interacts with RNAs containing short stretches of uridylates and its RRM2 can mediate the specific binding to uridylate-rich RNAs []. |
