| Primary Identifier | IPR023532 | Type | Family |
| Short Name | Nop10_arc-typ |
| description | Nop10 is a component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs). H/ACA snoRNPs are primarily responsible for catalysing the isomerisation of uridine to pseudouridine (Psi) in ribosomal and other cellular RNAs. The protein component of the H/ACA snoRNP consists of Cbf5, Gar1, Nhp2 and Nop10. The complex contains a stable core composed of Cbf5 and Nop10, to which Gar1 and Nhp2 subsequently bind. Nop10 has an essential role in the assembly and activity of these particles and binds directly to the Cbf5 to form the minimal active enzyme in archaea. The complex interacts with snoRNAs, Nop10 acting as a molecular adaptor for guiding snoRNP assembly []. |
