| Primary Identifier | IPR025929 | Type | Family |
| Short Name | INSIG_fam |
| description | This family contains a number of eukaryotic Insulin-induced proteins (INSIG-1 and INSIG-2) approximately 200 residues long. INSIG-1 and INSIG-2 are found in the endoplasmic reticulum and bind the sterol-sensing domain of SREBP cleavage-activating protein (SCAP), preventing it from escorting SREBPs to the Golgi. Their combined action permits feedback regulation of cholesterol synthesis over a wide range of sterol concentrations [, ].The INSIG family also includes NSG1 and NSG2 (INSIG homologues 1 and 2) []. |
