| Primary Identifier | IPR010911 | Type | Domain |
| Short Name | Rab_BD |
| description | This entry represents the Rab-binding domain.Rab are small GTPases implicated in vesicle trafficking. Like the other smallGTPases, Rab proteins act as molecular switches, with an active GTP-bound formthat interacts with its target or effector protein and an inactive GDP-boundform. A subgroup of Rab effectors contain in their N-terminal part a conservedregion of around 70 amino acid residues, the Rab-binding domain (RabBD). Insome Rab effector domains an atypical FYVE-type zinc finger is inserted in thecentral part [].The crystal structure of the Rab effector domain of Rabphilin-3A in complexwith Rab3A has been solved []. The structure consists of twolong helices separated by an atypical FYVE-type zinc finger which adopts aconformation similar to classical ones. The central zincfinger does not directly interact with Rab3A. The amino acids important forthis interaction are located around a short C-terminal motif (SGAWFF) and anacidic cluster in the N-terminal area. |
