| Primary Identifier | IPR022939 | Type | Family |
| Short Name | Nb(III)_bact/plant |
| description | This entry includes the Nitrobindin family members mostly from bacteria and plants. Mycobacterium tuberculosis Nb (Mt-Nb(III) is a peroxynitrite isomerase, which is a heme-binding protein able to scavenge peroxynitrite and to protect free L-tyrosine against peroxynitrite-mediated nitration, by acting as a peroxynitrite isomerase that converts peroxynitrite to nitrate []. This entry also includes ferric nitrobindin-like protein, lacks the conserved His residue that binds heme iron.Nitrobindins (Nbs) are evolutionary conserved all-β-barrel heme-proteins displaying a highly solvent-exposed heme-Fe(III) atom. Mycobacterium tuberculosis Nb (Mt-Nb(III) and the C terminus of Homo sapiens Nb (Hs-Nb(III)) share this β-barrel structure, suggesting that Nb may act as a sensor possibly modulating the THAP4 transcriptional activity residing in the N-terminal region []. Ferric nitrobindin-like proteins that lack the conserved His residue which binds heme iron are also included in the Nb family. |
