| Primary Identifier | IPR022925 | Type | Family |
| Short Name | RNA_Hydrolase_NudC |
| description | This entry represents NAD-capped RNA hydrolase NudC from bacteria. NudC is a mRNA decapping enzyme that specifically removes the nicotinamide adenine dinucleotide (NAD) cap from a subset of mRNAs by hydrolysing the diphosphate linkage to produce nicotinamide mononucleotide (NMN) and 5' monophosphate mRNA. This enzyme has preference for mRNAs with a 5'-end purine and catalyses the hydrolysis of a broad range of dinucleotide pyrophosphates. NudC assemblies into a homodimer with the appearance of a butterfly. Each monomer shows two tandem Nudix-fold domains, a N-terminal and a C-terminal, and an extended zinc-binding motif in-between. As a subgroup of the Nudix hydrolase family, NudC has a conserved Nudix motif [, ]. |
