| Primary Identifier | IPR031291 | Type | Family |
| Short Name | Anoctamin-10 |
| description | The anoctamin/TMEM16 family members include Ano1-10 (TMEM16A-J). They are membrane proteins involved in a variety of physiological functions, such as ion transport and ion channel regulation. TMEM16A and 16B are Ca(2+)-dependent Cl(-) channels; TMEM16C, 16D, 16F, 16G, and 16J have been classified as Ca(2+)-dependent lipid scramblases []. The anoctamin/TMEM16 family might have diverged in two or three different subclasses, channels, scramblases and dual-function channel/scramblases [].Anoctamin-10 (Ano10, TMEM16K) does not exhibit calcium-activated chloride channel (CaCC) activity. It has been suggested that Ano10 has an intracellular rather than plasma membrane function due to its poor membrane expression []. |
