| Primary Identifier | IPR044417 | Type | Domain |
| Short Name | PRDM7_9_PR-SET |
| description | This entry represents the PR/SET domain found in PR domain zinc finger protein 7 and 9 (PRDM7/9). PRDM7 (also termed PR domain-containing protein 7) is a primate-specific histone methyltransferase that is the result of a recent gene duplication of PRDM9. It selectively catalyses the trimethylation of H3 lysine 4 (H3K4me3) []. PRDM9 (also termed PR domain-containing protein 9) is a histone methyltransferase that specifically trimethylates 'Lys-4' of histone H3 (H3K4me3) during meiotic prophase and is essential for proper meiotic progression. It also efficiently mono-, di-, and trimethylates H3K36. Aberrant PRDM9 expression is associated with genome instability in cancer [, , , ]. PRDM9 has also been shown to be able to performs intramolecular automethylation on multiple lysine residues localised to a lysine-rich region on the post-SET domain [].The PRDM family members are characterised by the presence of a N-terminal PR (PRDI-BF1 and RIZ1 homology) domain followed by multiple zinc fingers which confer DNA binding activity. PR domains are only distantly related to the classical SET methyltransferase domains []. They are involved in epigenetic regulation of gene expression through their intrinsic histone methyltransferase activity or via interactions with other chromatin modifying enzymes []. |
