| Primary Identifier | IPR044409 | Type | Domain |
| Short Name | PRDM15_PR-SET |
| description | This entry represents the PR/SET domain found in PR domain zinc finger protein 15 (PRDM15). PRDM15 plays an essential role as a chromatin factor that modulates the transcription of upstream regulators of WNT and MAPK-ERK signaling to safeguard naive pluripotency [].The PRDM family members are characterised by the presence of a N-terminal PR (PRDI-BF1 and RIZ1 homology) domain followed by multiple zinc fingers which confer DNA binding activity. PR domains are only distantly related to the classical SET methyltransferase domains []. They are involved in epigenetic regulation of gene expression through their intrinsic histone methyltransferase activity or via interactions with other chromatin modifying enzymes []. |
