| Primary Identifier | IPR044402 | Type | Domain |
| Short Name | PRDM8_PR/SET |
| description | This entry represents the PR/SET domain found in PR domain zinc finger protein 8 (PRDM8). PRDM8 is a transcription factor that plays an essential role in the development of the mammalian retina [].The PRDM family members are characterised by the presence of a N-terminal PR (PRDI-BF1 and RIZ1 homology) domain followed by multiple zinc fingers which confer DNA binding activity. PR domains are only distantly related to the classical SET methyltransferase domains []. They are involved in epigenetic regulation of gene expression through their intrinsic histone methyltransferase activity or via interactions with other chromatin modifying enzymes []. |
