| Primary Identifier | IPR020445 | Type | Family |
| Short Name | TNFR_4 |
| description | The tumour necrosis factor (TNF) receptor (TNFR) superfamily comprises more than 20 type I transmembrane proteins. Family members are defined based on similarity in their extracellular domain, a region that contains many cysteine residues arranged in a specific repetitive pattern []. The cysteines allow formation of an extended rodlike structure, responsible for ligand binding []. Upon receptor activation, different intracellular signalling complexes are assembled for different members of the TNFR superfamily, depending on their intracellular domains and sequences []. Activation of TNFRs can therefore induce a range of disparate effects, including cell proliferation, differentiation, survival, or apoptotic cell death, depending upon the receptor involved [, ]. TNFRs are widely distributed and play important roles in many crucial biological processes, such as lymphoid and neuronal development, innate and adaptive immunity, and maintenance of cellular homeostasis []. Drugs that manipulate their signalling have potential roles in the prevention and treatment of many diseases, such as viral infections, coronary heart disease, transplant rejection, and immune disease []. This entry represents TNF receptor 4 (also known as OX40 and CD134 antigen) is expressed primarily on activated CD4(+) T cells. Activation of the receptor increases the proinflammatory activity of these cells and enhances their long-term survival []. |
