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Protein Domain : Exonuclease 1-like, PIN-like domain

Primary Identifier  IPR044752 Type  Domain
Short Name  PIN-like_EXO1
description  This is the PIN domain found in animal exonuclease-1 (EXO1) and its paralogue from yeasts, Din7. EXO1 is a 5'-3'-exonuclease that functions in DNA mismatch repair (MMR), double-strand break repair, replication, recombination and telomere integrity [, , ]. It also possesses a flap-endonuclease activity [, ], being a member of the Flap endonuclease-like (FEN-like) family, which are structure-specific endonucleases capable of cleaving single-stranded DNA or RNA at the bifurcated end of a base-paired duplex. DIN7 is involved in mitochondrial DNA repair and replication [].PIN domains belong to a large nuclease superfamily, which share a common core fold consisting of a three-layered α/β/α core motif with a central, parallel five-stranded β-sheet. Its active site, possess invariant acidic amino acid residues and binds one or more divalent metal ions [, ].

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4 Protein Domain Regions