| Primary Identifier | IPR017147 | Type | Family |
| Short Name | Tricalbin |
| description | Tricalbins constitute a synaptotagmin-like yeast protein family. Tricalbins contain several copies of C2 domains and are thought to be involved in membrane traffic [, , ]. As extended synaptotagmins, tricalbins also possess a synaptotagmin-like mitochondrial lipid-binding protein (SMP) domain that is found in proteins localized to ER-organelle contact sites []. The ER-plasma membrane tethering function of tricalbins mediates the formation of ER-PM contacts sites []which are thought to mediate transport glycerolipids between the two bilayers []. The family consists of three members: tricalbin 1-3. The C2 domains of tricalbins 1 and 3 are calcium-dependent lipid-binding units comparable to mammalian synaptotagmin C2 domains, while tricalbin 2 does not seem to bind lipids in response to calcium signaling []. |
