| Primary Identifier | IPR030101 | Type | Family |
| Short Name | HARP(SMARCAL1) |
| description | HARP (HepA-related protein; also known as SMARCAL1 and DNA-dependent ATPase A) is an ATP-driven annealing helicase that acts throughout the genome to re-anneal stably unwound DNA []. It helps to stabilise stalled replication forks and facilitate DNA repair during replication [, ]. SMARCAL1 binds directly to forked DNA structures or can be recruited to replication forks via interaction with the single-stranded DNA binding protein RPA []. Mutations in the HARP gene are responsible for a pleiotropic disorder known as Schimke immuno-osseous dysplasia (SIOD) []. |
