| Primary Identifier | IPR007834 | Type | Family |
| Short Name | DSS1_SEM1 |
| description | This family includes yeast Sem1 and its mammalian homologue, DSS1.Sem1/DSS1 (also known as rpn15) is a component of lid subcomplex of 26S proteasome regulatory subunit [, , ]. Besides being a subunit of the 26S proteasome, Sem1/DSS1 associates with other protein complexes []. It is a component of the nuclear pore complex (NPC)-associated TREX-2 complex that is required for transcription-coupled mRNA export, and the COP9 signalosome, which is involved in deneddylation [, , ]. Loss of DSS1 in humans has been associated with split hand/split foot malformations []. |
