| Primary Identifier | IPR030790 | Type | Family |
| Short Name | SPRY4 |
| description | Protein sprouty homologue 4 (SPRY4) belongs to the sprouty family, whose members are inhibitors of the Ras-ERK pathway downstream of various receptor tyrosine kinases. SPRY4 is a feedback negative regulator of FGFs-induced ERK1/2 signalling. It suppresses Ras-independent ERK activation by binding to Raf1 []. It may function as a tumour suppressor in endometrial adenocarcinoma []. It plays a critical role in developing inflammatory Th17 cells in Th17 cell-driven autoimmune diseases []. |
