| Primary Identifier | IPR032675 | Type | Homologous_superfamily |
| Short Name | LRR_dom_sf |
| description | This superfamily represents a leucine-rich repeat (LRR), right-handed beta-alpha superhelix domain, such as that found in bacterial invasion protein internalin []or in the L domain from members of the epidermal growth-factor receptor (EGFR) family [].Leucine-rich repeats (LRR) consist of 2-45 motifs of 20-30 amino acids in length that generally folds into an arc or horseshoe shape []. LRRs occur in proteins ranging from viruses to eukaryotes, and appear to provide a structural framework for the formation of protein-protein interactions [, ].Proteins containing LRRs include tyrosine kinase receptors, cell-adhesion molecules, virulence factors, and extracellular matrix-binding glycoproteins, and are involved in a variety of biological processes, including signal transduction, cell adhesion, DNA repair, recombination, transcription, RNA processing, disease resistance, apoptosis, and the immune response []. |
