| Primary Identifier | IPR030060 | Type | Family |
| Short Name | IRTKS |
| description | IRTKS (insulin receptor tyrosine kinase substrate; brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 or BAIAP2L1) is an I-BAR (Bin/amphipysin/Rvs) domain containing protein. I-BAR domain is a type of the BAR domain, which forms an anti-parallel all-helical dimer, with a curved (banana-like) shape, that promotes membrane tubulation. The BAR domain containing proteins can be classified into three types: BAR, F-BAR and I-BAR. BAR and F-BAR proteins generate positive membrane curvature, while I-BAR proteins induce negative curvature [].IRTKS binds small GTPase Rac rather than Cdc42 []. It serves as an adaptor of the insulin receptor (IR), modulates IR-IRS1-PI3K-AKT signalling via regulating the phosphorylation of IR []. It has been linked to the formation of actin-rich membrane protrusions, called pedestals, during the infection process of enterohemorrhagic Escherichia coli []. |
