| Primary Identifier | IPR007724 | Type | Family |
| Short Name | Poly_GlycHdrlase |
| description | Poly(ADP-ribose) glycohydrolase (PARG) () is a ubiquitously expressed exo- and endoglycohydrolase which catalyses the hydrolysis of the O-glycosidic linkages of ADP-ribose polymers, reversing the effects of poly(ADP-ribose) [, , , , ]. It generates mono-ADP-ribosylated proteins in cells, due to its ability of degrading poly(ADP-ribose) without cleaving the terminal protein-ribose bond []. PARG is also involved in the synthesis of nuclear ATP, which is required for extensive chromatin remodeling events []. This protein mediates oxidative and excitotoxic neuronal death [].Arabidopsis thaliana PARG1 is involved in abiotic stress responses and DNA repair [, ]. |
