| Primary Identifier | IPR031267 | Type | Family |
| Short Name | SOX-12 |
| description | SYR-related high mobility group (HMG) box (SOX) family proteins are a conserved group of transcriptional regulators defined by the presence of a highly conserved HMG box domain that mediates DNA binding []. SOX-12, together with SOX-4 and SOX-11, belongs to the subgroup C of the SOX gene family, with SOX-4 and SOX-11 being function redundantly with SOX-12 [, ]. SOX-12 plays a critical role in embryonic development and cell-fate determination during organogenesis [, ]. It has been shown to promote hepatocellular carcinoma invasion and metastasis []. Sox-12 is involved in the development of peripheral T regulatory cells under inflammatory conditions and sufficient to promote Foxp3 expression in CD4+ T cells []. |
