| Primary Identifier | IPR030390 | Type | Active_site |
| Short Name | MeTrfase_TrmA_AS |
| description | In Escherichia coli, the trmA protein is a tRNA (uracil-5-)-methyltransferase() that catalyses the S-adenosylmethionine dependent methylation of U54 in all tRNAs. Orthologues of trmA are found in many eubacterial species. A number of uncharacterised homologues of trmA have been found []:Escherichia coli hypothetical protein ygcA and HI0333, the correspondingHaemophilus influenzae protein.Haemophilus influenzae hypothetical protein HI0958.Chlamydia trachomatis protein HOM1.Fission yeast hypothetical protein SpAC4G8.07c.It is probable that ygcA/HI0333 and HI0958 are responsible for themethylation of U747 and U1939 in 23S rRNA. In trmA, a cysteine is known toparticipate in the catalytic mechanism by forming a covalent adduct to C6 ofuracil.This entry represents a conserved region that includes the active site cysteine. |
