| Primary Identifier | IPR045125 | Type | Family |
| Short Name | Sub1/Tcp4-like |
| description | This entry represents a group of RNA polymerase II transcriptional coactivators, including Sub1 from budding yeasts, Tcp4 from animals and KIWI/KELP from plants.Tcp4, also known as p15, is a coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. It has a bipartite structure composed of an amino-terminal regulatory domain and a carboxy-terminal cryptic DNA-binding domain []. The DNA-binding activity of the carboxy-terminal is disguised by the amino-terminal p15 domain. Activity is controlled by protein kinases that target the regulatory domain.Sub1 facilitates elongation by influencing enzymes that modify RNAP II (RNA polymerase II) []. It is required for NHEJ repair of DSBs in plasmid DNA, but not in chromosomal DNA [].KELP has been shown to bind to movement protein (MP) of tomato mosaic virus (ToMV) and interferes with virus cell-to-cell movement []. |
